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稳定型心绞痛患者硝苯地平突然停药后的撤药现象。

Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris.

作者信息

Martsevich S Y, Koutishenko N, Metelitsa V I

机构信息

Department of Preventive Pharmacology, Research Centre for Preventive Medicine of Russia, Moscow.

出版信息

Int J Cardiol. 1993 Dec 31;42(3):298-301. doi: 10.1016/0167-5273(93)90065-o.

DOI:10.1016/0167-5273(93)90065-o
PMID:8138342
Abstract

We investigated the effect of abrupt cessation of nifedipine after regular administration (20 mg, four times daily) for 5 weeks in seven patients with stable angina pectoris. A rebound decrease in exercise tolerance and increase of exercise-induced myocardial ischaemia were registered on the first day of nifedipine withdrawal.

摘要

我们研究了7例稳定型心绞痛患者在规律服用硝苯地平（20毫克，每日4次）5周后突然停药的影响。在硝苯地平停药的第一天，记录到运动耐量出现反弹性下降以及运动诱发的心肌缺血增加。

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1
Withdrawal phenomenon after abrupt cessation of nifedipine in stable angina pectoris.稳定型心绞痛患者硝苯地平突然停药后的撤药现象。
Int J Cardiol. 1993 Dec 31;42(3):298-301. doi: 10.1016/0167-5273(93)90065-o.
2
[The nifedipine withdrawal syndrome in patients with stable stenocardia of effort].[劳力性稳定型心绞痛患者的硝苯地平撤药综合征]
Ter Arkh. 1995;67(6):8-10.
3
Withdrawal effects of antianginal therapy: comparison of isosorbide dinitrate and nifedipine.抗心绞痛治疗的撤药效应：硝酸异山梨酯与硝苯地平的比较
Int J Cardiol. 1998 Apr 1;64(2):137-44. doi: 10.1016/s0167-5273(98)00020-5.
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Abrupt cessation of short-term continuous treatment with isosorbide dinitrate may cause a rebound increase in silent myocardial ischaemia in patients with stable angina pectoris.对于稳定型心绞痛患者，突然停止短期连续使用硝酸异山梨酯治疗可能会导致无症状性心肌缺血反弹增加。
Heart. 1996 May;75(5):447-50. doi: 10.1136/hrt.75.5.447.
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[The possibility of the development of isosorbide dinitrate and nifedipine withdrawal syndromes in patients with stable stenocardia of effort].[劳力性稳定型心绞痛患者中出现硝酸异山梨酯和硝苯地平撤药综合征的可能性]
Ter Arkh. 1997;69(9):47-51.
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Acute nifedipine withdrawal: consequences of preoperative and late cessation of therapy in patients with prior unstable angina.急性硝苯地平撤药：既往有不稳定型心绞痛患者术前及晚期停药的后果
J Am Coll Cardiol. 1984 Aug;4(2):382-8. doi: 10.1016/s0735-1097(84)80230-2.
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[Comparison of the effects and safety of atenolol and nifedipine in the treatment of angina pectoris].
Vnitr Lek. 1993 Apr;39(4):345-52.
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Development of tolerance to nifedipine in patients with stable angina pectoris.稳定型心绞痛患者对硝苯地平耐受性的发展
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Combination therapy with metoprolol and nifedipine versus monotherapy in patients with stable angina pectoris. Results of the International Multicenter Angina Exercise (IMAGE) Study.美托洛尔与硝苯地平联合治疗与单药治疗稳定型心绞痛患者的疗效比较。国际多中心心绞痛运动（IMAGE）研究结果
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Effects of nifedipine and diltiazem on myocardial ischemia in patients with severe stable angina pectoris treated with nitrates and beta-blockers.硝苯地平和地尔硫䓬对使用硝酸盐类和β受体阻滞剂治疗的重度稳定型心绞痛患者心肌缺血的影响。
J Cardiovasc Pharmacol. 1992 Dec;20(6):864-9. doi: 10.1097/00005344-199212000-00003.

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Abrupt cessation of short-term continuous treatment with isosorbide dinitrate may cause a rebound increase in silent myocardial ischaemia in patients with stable angina pectoris.对于稳定型心绞痛患者，突然停止短期连续使用硝酸异山梨酯治疗可能会导致无症状性心肌缺血反弹增加。
Heart. 1996 May;75(5):447-50. doi: 10.1136/hrt.75.5.447.