Hachida M, Nonoyama M, Hanayama N, Hoshi H, Bonkohara Y, Koyanagi H
Department of Cardiovascular Surgery, Heart Institute of Japan.
Nihon Kyobu Geka Gakkai Zasshi. 1994 Feb;42(2):267-72.
The patient with dilated cardiomyopathy (NYHA grade 4) underwent cardiac transplantation at University of California, Los Angeles. Postoperative management in our institute consisted 1) cardiac biopsy, 2) measurement of blood concentration of cyclosporin, 3) serum anti-CMV titer, 3) echo cardiography, 4) counts of lymphocyte subsets. Cardiac rejection (Ib) was observed 2 months after transplantation and steroid pulse therapy (methylprednisone 500 mg/day) was performed for 3 days. Blood concentration of cyclosporin was decreased with administration of probucol and increased with diltiazem. Presently, the patient is stable and back to normal work.
这位扩张型心肌病患者(纽约心脏协会心功能分级4级)在加利福尼亚大学洛杉矶分校接受了心脏移植手术。我们研究所的术后管理包括:1)心脏活检;2)测量环孢素血药浓度;3)血清抗巨细胞病毒滴度;3)超声心动图检查;4)淋巴细胞亚群计数。移植后2个月观察到心脏排斥反应(Ib级),并进行了3天的类固醇冲击治疗(甲泼尼龙500毫克/天)。服用普罗布考后环孢素血药浓度降低,服用地尔硫䓬后环孢素血药浓度升高。目前,患者情况稳定,已恢复正常工作。