Ohata M, Sugiura K, Otsuka S, Nonaka K, Nakazawa M
Department of Clinical Laboratory, Shizuoka Red Cross Hospital.
Rinsho Ketsueki. 1994 Feb;35(2):127-34.
A fifty five-year-old male presenting as FAB M6 had blasts that were positive both for erythroblastic and megakaryocytic surface makers, i.e., carbonic anhydrase I, CD36 and CD41. HLA-DR and cD71 were also positive. In a very small portion, CD33 and glycophorin A were also positive. By Giemsa staining, these blasts were relatively large and had basophilic cytoplasm. By electroscopic study, PPO was negative and showed ferritin particles, theta granules and iron containing mitochondria in cytoplasm. Chromosome analysis revealed major karyotypic abnormality (MAKA). After initial treatment with blood transfusion, prednisolone and exymetholone, CD41b increased in positive ratio. Trial of remission induction with BHAC-DMP failed and patient died in 5 months.
一名55岁男性，表现为FAB M6型，其原始细胞对成红细胞和巨核细胞表面标志物均呈阳性，即碳酸酐酶I、CD36和CD41。HLA - DR和cD71也呈阳性。在非常小的一部分中，CD33和血型糖蛋白A也呈阳性。吉姆萨染色显示，这些原始细胞相对较大，具有嗜碱性细胞质。电镜研究显示，血小板过氧化物酶（PPO）呈阴性，细胞质中可见铁蛋白颗粒、θ颗粒和含铁线粒体。染色体分析显示存在主要核型异常（MAKA）。在最初接受输血、泼尼松龙和羟甲烯龙治疗后，CD41b阳性率增加。采用BHAC - DMP进行缓解诱导试验失败，患者在5个月后死亡。
