Chakrabarti S, Diocee M, Henry S, Jeffery J, Rush D, Gough J
Department of Pathology, University of Manitoba Health Sciences Centre, Winnipeg, Canada.
Nephron. 1994;66(2):136-9. doi: 10.1159/000187790.
We studied anionic sites on the glomerular basement membrane in patients with chronic renal transplant rejection having clinical and histological features of transplant glomerulopathy. All patients had significant proteinuria (greater than 1 g/24 h as well as light- and electron-microscopic features very like focal segmental glomerulosclerosis, though no patient had that disease in the native kidney. A significant reduction in the density and absolute number of anionic sites was observed compared with controls and with patients having stable graft function. The findings suggest that the loss of anionic sites may play an important part in the pathogenesis of transplant glomerulopathy.
我们研究了患有慢性肾移植排斥反应且具有移植肾小球病临床和组织学特征的患者肾小球基底膜上的阴离子位点。所有患者均有显著蛋白尿（大于1g/24小时），且光镜和电镜特征非常类似于局灶节段性肾小球硬化，尽管没有患者在其原生肾中患有该疾病。与对照组以及移植肾功能稳定的患者相比，观察到阴离子位点的密度和绝对数量显著降低。这些发现表明，阴离子位点的丧失可能在移植肾小球病的发病机制中起重要作用。
