Bösze P
Országos Onkológiai Intézet, Nögyógyászati Onkológiai Osztály, Budapest.
Orv Hetil. 1994 Feb 27;135(9):459-64.
This paper gives an overview of the familial ovarian cancer. Ovarian cancer prone families defined as two or more first or second degree relatives with ovarian cancer, are of clinical importance because first or second degree family members of affected women are at risk of developing ovarian cancer. These women need surveillance including prophylactic oophorectomy in those with increased risk. Women with hereditary ovarian cancer are at the greatest risk. Familial ovarian cancer studies are also important in terms of research. They provide the best hope of identifying a gene involved in the genesis of ovarian cancer. There is good evidence that such a gene is likely to be involved in the development of non-familial ovarian cancer as well. This might be a clue to understanding the biology of ovarian cancer. Therefore ovarian cancer prone families should be identified and, since familial ovarian cancer is rare, available details about affected and non-affected family members should be registered at least at national level. The author set up the Hungarian Registry for familial ovarian carcinoma at the National Institute of Oncology Budapest.
本文概述了家族性卵巢癌。易患卵巢癌的家族被定义为有两名或更多名患有卵巢癌的一级或二级亲属，具有临床重要性，因为受影响女性的一级或二级家庭成员有患卵巢癌的风险。这些女性需要进行监测，包括对风险增加者进行预防性卵巢切除术。遗传性卵巢癌女性的风险最大。家族性卵巢癌研究在研究方面也很重要。它们为确定参与卵巢癌发生的基因提供了最大希望。有充分证据表明，这样一个基因也可能参与非家族性卵巢癌的发展。这可能是理解卵巢癌生物学特性的一条线索。因此，应该识别出易患卵巢癌的家族，并且由于家族性卵巢癌较为罕见，至少应在国家层面登记有关受影响和未受影响家庭成员的现有详细信息。作者在布达佩斯国家肿瘤研究所设立了匈牙利家族性卵巢癌登记处。
