Wako H, Hatakeyama T, Kamihara M, Wada S
Jikken Dobutsu. 1975 Oct;24(4):161-71. doi: 10.1538/expanim1957.24.4_161.
New-born cynomolgus monkeys were sucessfully reared by artificial nursing that was started just afterbirth with a 12% solution of a commercially prepared powdered-milk (Yukijirushi, P 7a) containing 13.3g of protein per 100g. Marked growth-retardation was observed in baby cynomolgus monkeys fed on a 12% solution of the modified P 7a milk containing only 6.6g of protein per 100g to which lactose was supplemented to give a baby monkey the same caloric value as that of the original P 7a milk. These artificially reared cynomolgus monkeys manifested various kinds of abnormal behavior such as self-clasping, autism-like self mouthing, huddling, stereotype rocking, head-knocking, autoerotism, fear, aggression, etc.. Generally, development of these abnormal behaviors was more noticeable in the monkeys nursed with a milk bottle fixed to the side of a cage without human contact than in the monkeys nursed by a care-taker with bodily touching. These qualitative observational results indicate that the new-born cynomolgus monkey can be used as a model of the human baby for research into the relationship between malnutrition and abnormal physical and mental growth.
新生食蟹猴通过人工哺乳成功饲养,人工哺乳在出生后立即开始,使用市售奶粉(雪印,P 7a)的12%溶液,每100克含有13.3克蛋白质。在以每100克仅含6.6克蛋白质的改良P 7a牛奶的12%溶液喂养的食蟹猴幼崽中观察到明显的生长迟缓,该溶液添加了乳糖以使幼猴获得与原始P 7a牛奶相同的热量值。这些人工饲养的食蟹猴表现出各种异常行为,如自我抱紧、自闭症样的自我吮嘴、挤作一团、刻板摇晃、撞头、自慰、恐惧、攻击等。一般来说,这些异常行为的发展在用固定在笼子一侧的奶瓶哺乳且无人接触的猴子中比在由护理人员进行身体接触哺乳的猴子中更明显。这些定性观察结果表明,新生食蟹猴可作为人类婴儿的模型,用于研究营养不良与身心异常生长之间的关系。