Ghaly E S, Malavé M I, Rivera W J, Martí A
University of Puerto Rico, School of Pharmacy, Department of Pharmaceutical Sciences, San Juan 00936-5067.
P R Health Sci J. 1993 Dec;12(4):255-8.
Sustained release theophylline tablets containing stearic acid wax and lactose fast flo as chanelling agent were prepared and evaluated. The fusion technique was used for dispersing the drug in the different levels of stearic acid. The release rate of theophylline from the prepared tablets increased with the increase of the level of the channeling material in the formula. The drug release from tablets containing high level of wax (30 and 60%) and low level of channeling material (59% and 29%) followed the diffusion controlled model for inert porous matrix. The drug release increased significantly with the increase of lactose fast flow level in the formula. After 2 hours of testing dissolution, the tablets start to erode and the mechanism of drug release deviate from the diffusion controlled model. The mechanism of drug release was dependent on the level of the channeling material in the matrix.
制备并评估了含有硬脂酸蜡和乳糖速流作为通道剂的缓释茶碱片。采用熔融技术将药物分散在不同水平的硬脂酸中。所制备片剂中茶碱的释放速率随处方中通道材料水平的增加而增加。含有高蜡水平（30%和60%）和低通道材料水平（59%和29%）的片剂的药物释放遵循惰性多孔基质的扩散控制模型。药物释放随处方中乳糖速流水平的增加而显著增加。在进行2小时溶出测试后，片剂开始侵蚀，药物释放机制偏离扩散控制模型。药物释放机制取决于基质中通道材料的水平。
