Rubio M R, Ghaly E S
School of Pharmacy, University of Puerto Rico, San Juan 00936-5067.
P R Health Sci J. 1993 Dec;12(4):269-72.
Spheres of acetaminophen (APAP) were prepared via the cross linking agglomeration technique and were successfully compacted into tablets. The drug load in all formulations was 20% w/v, the cross linking agent varied from 1% w/v to 20% w/v, the polymer levels varied from 1% w/v to 4% w/v and the residence time from 3 to 60 minutes. The data obtained showed that increasing the concentration of the cross linking agent to 5% w/v or more showed no reduction in drug release rate. Also varying the residence time of the spheres in the cross linking solution showed no detectable differences in the drug release from spheres. Formulations prepared with 3% w/v and or 4% w/v polymer level showed higher drug release than formulation prepared with lower polymer levels.
通过交联团聚技术制备了对乙酰氨基酚（APAP）微球，并成功压制成片剂。所有制剂中的药物负载量为20% w/v，交联剂的含量从1% w/v变化到20% w/v，聚合物水平从1% w/v变化到4% w/v，停留时间从3分钟到60分钟。获得的数据表明，将交联剂浓度增加到5% w/v或更高时，药物释放速率没有降低。同样，改变微球在交联溶液中的停留时间，微球的药物释放也没有可检测到的差异。聚合物水平为3% w/v和/或4% w/v制备的制剂比聚合物水平较低制备的制剂显示出更高的药物释放。
