Gardner B N, Small D M
Gastroenterology. 1976 Mar;70(3):403-7.
A primate model is described that permits separate but simultaneous sampling of both bile and pancreatic fluid without altering the normal enterohepatic circulation. Simultaneous biliary and pancreatic dose response curves are presented to contrast the production of bile with both pancreatic flow and the secretion of pancreatic protein and bicarbonate. The data show that in the cholecystectomized animal both cholecystokinin and secretin increase bile flow at doses that produce appropriate submaximal responses from the pancreas. Both these hormones, therefore, are physiologically important in regulating flow. Further, over a wide dose range (0.2 to 2.3 U per kg) secretion has the major effect on bile flow, and pancreatic flow, and pancreatic bicarbonate secretion, whereas cholyecystokinin has the major effect on pancreatic protein secretion.
本文描述了一种灵长类动物模型，该模型能够在不改变正常肠肝循环的情况下，分别同时采集胆汁和胰液。文中给出了同时的胆汁和胰液剂量反应曲线，以对比胆汁分泌与胰液分泌量以及胰蛋白和碳酸氢盐分泌之间的关系。数据表明，在胆囊切除的动物中，胆囊收缩素和促胰液素在产生胰腺适度亚最大反应的剂量下均可增加胆汁流量。因此，这两种激素在调节胆汁流量方面均具有重要的生理意义。此外，在较宽的剂量范围内（每千克0.2至2.3单位），促胰液素对胆汁流量、胰液流量和胰液碳酸氢盐分泌起主要作用，而胆囊收缩素对胰蛋白分泌起主要作用。
