Sakamoto T, Fujimura M, Townsend C M, Greeley G H, Thompson J C
Department of Surgery, University of Texas Medical Branch, Galveston 77550.
Surg Gynecol Obstet. 1988 Jan;166(1):11-6.
The results of previous studies from our laboratory have shown that neurotensin can stimulate pancreatic secretion of bicarbonate and protein. This study was done to compare the stimulatory action of neurotensin on pancreatic exocrine secretion in conscious dogs to those of secretin and cholecystokinin (CCK). Six dogs with chronic pancreatic and gastric fistulas were given hydrochloric acid intraduodenally or CCK-8 intravenously to produce maximal bicarbonate or protein secretion. Neurotensin was then given intravenously in combination with intraduodenal hydrochloric acid or intravenous CCK-8. Incremental bicarbonate outputs in response to intraduodenal hydrochloric acid alone were measured and compared with intraduodenal hydrochloric acid plus intravenous neurotensin. Intravenous administration of neurotensin augmented pancreatic bicarbonate and protein secretory responses to a maximal dose of intraduodenal hydrochloric acid. Incremental protein responses to intravenous CCK-8 alone were measured and compared to intravenous CCK-8 plus intravenous neurotensin. Incremental bicarbonate responses to intravenous CCK-8 alone were compared with intravenous CCK-8 plus intravenous neurotensin. Similarly, intravenous neurotensin augmented pancreatic protein and bicarbonate secretory responses to a maximal dose of intravenous CCK-8. The results of this study indicate that neurotensin may stimulate pancreatic secretion of protein and bicarbonate by mechanisms which are different from those of CCK and secretin. Neurotensin apparently exerts its action through specific neurotensin receptors.
我们实验室之前的研究结果表明，神经降压素可刺激胰腺分泌碳酸氢盐和蛋白质。本研究旨在比较神经降压素对清醒犬胰腺外分泌的刺激作用与促胰液素和胆囊收缩素（CCK）的刺激作用。对六只患有慢性胰腺和胃瘘的犬，经十二指肠内给予盐酸或静脉内给予CCK-8，以产生最大碳酸氢盐或蛋白质分泌。然后将神经降压素与十二指肠内盐酸或静脉内CCK-8联合静脉给药。测量单独对十二指肠内盐酸的碳酸氢盐增量输出，并与十二指肠内盐酸加静脉内神经降压素进行比较。静脉注射神经降压素可增强胰腺对最大剂量十二指肠内盐酸的碳酸氢盐和蛋白质分泌反应。测量单独对静脉内CCK-8的蛋白质增量反应，并与静脉内CCK-8加静脉内神经降压素进行比较。将单独对静脉内CCK-8的碳酸氢盐增量反应与静脉内CCK-8加静脉内神经降压素进行比较。同样，静脉注射神经降压素可增强胰腺对最大剂量静脉内CCK-8的蛋白质和碳酸氢盐分泌反应。本研究结果表明，神经降压素可能通过与CCK和促胰液素不同的机制刺激胰腺分泌蛋白质和碳酸氢盐。神经降压素显然通过特定的神经降压素受体发挥作用。
