Jamaa M, Laine-Cessac P, Victor J, Tadei A, Allain P
Service de cardiologie, C.H.R.U., Angers.
Therapie. 1993 May-Jun;48(3):259-62.
An intensive pharmacovigilance survey was carried out over the course of 1 year in cardiology department which revealed 64 reports of adverse drug reactions among 61 hospitalised patients, giving an overall incidence of 2.3%. Most of the patients in whom adverse drug reactions were recorded were elderly and female. The most common adverse events were cardiovascular (72%) and haemorrhagic (9%), and related to drugs given for the treatment of cardiovascular disorders. The symptoms originating from drug therapy were dominated by sinus arrhythmias (25 cases), linked to drugs co-administered that have potentially similar cardiac pharmacodynamic effects. Seven cases of "torsades de pointe" were also observed.
在心脏科进行了为期1年的强化药物警戒调查，结果显示，61名住院患者中有64例药物不良反应报告，总发生率为2.3%。记录到药物不良反应的患者大多为老年女性。最常见的不良事件是心血管方面的（72%）和出血性的（9%），且与用于治疗心血管疾病的药物有关。药物治疗引发的症状以窦性心律失常为主（25例），与同时使用的具有潜在相似心脏药效学作用的药物有关。还观察到7例“尖端扭转型室速”。
