Fuse H, Okumura M, Sakamoto M, Kazama T, Katayama T
Department of Urology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Urol Int. 1994;52(1):9-13. doi: 10.1159/000282561.
Epidermal growth factor (EGF) content in seminal plasma of 17 patients with androgen deficiency (12 Klinefelter's syndrome and 5 hypogonadotropic hypogonadism) was determined before and after hormone replacement. No significant increase of plasma testosterone level was demonstrated after testosterone administration in Klinefelter's syndrome, although the level in 4 of 5 patients with hypogonadotropic hypogonadism reached the normal range. In 16 patients, except 1 with hypogonadotropic hypogonadism with no increase of blood testosterone level, prostate volume increased after hormone therapy, and volumes after treatment were significantly larger than those before treatment. On the other hand, EGF concentration in seminal plasma remained at the pretreatment level in most patients. It is therefore concluded that although the prostate volume increases to almost normal after treatment, prostate function does not improve in most patients, indicating that in patients with hypogonadotropic hypogonadism fertility potential may remain low, even if they obtain normal seminal parameters after treatment.
测定了17例雄激素缺乏患者（12例克兰费尔特综合征和5例低促性腺激素性性腺功能减退症患者）激素替代治疗前后精浆中的表皮生长因子（EGF）含量。在克兰费尔特综合征患者中，睾酮给药后血浆睾酮水平未显示出显著升高，尽管5例低促性腺激素性性腺功能减退症患者中有4例的睾酮水平达到了正常范围。16例患者中，除1例低促性腺激素性性腺功能减退症患者血睾酮水平未升高外，激素治疗后前列腺体积增大，治疗后的体积显著大于治疗前。另一方面，大多数患者精浆中的EGF浓度维持在治疗前水平。因此得出结论，尽管治疗后前列腺体积几乎恢复正常，但大多数患者的前列腺功能并未改善，这表明低促性腺激素性性腺功能减退症患者即使治疗后精液参数正常，生育潜能可能仍较低。
