Tkác I, Tkácová R, Molcányiová A, Mudríková T, Takác M
IV. interná klinika LF UPJS Kosice.
Vnitr Lek. 1994 Jan;40(1):17-20.
Serum lipid concentrations were assessed in 147 type 2 diabetics. The patients were divided into different sub-groups in order to follow up different factors which could have an impact on serum lipids. The mean total cholesterol concentrations were significantly higher in diabetic women as compared with men. The authors did not reveal significant differences in lipid concentrations between obese and non-obese diabetics. Hypertensive diabetics had higher mean total cholesterol levels and LDL-cholesterol levels, as compared with diabetic patients without hypertension. Patients using oral antidiabetics had significantly higher mean triglyceride levels and lower HDL-cholesterol levels, as compared with insulin-treated diabetics. In a multiple stepwise regression analysis correlated triglycerides with three independent variables: total cholesterol, diastolic blood pressure and inversely with HDL-cholesterol. On the other hand, total cholesterol correlated significantly with triglycerides, HDL-cholesterol and proteinuria/day. To sum up, it may be stated, that the results of the present investigation are consistent with Reaven's concept of the syndrome X, however the cholesterol concentration is affected also by the proteinuria.
对147名2型糖尿病患者的血脂浓度进行了评估。为了追踪可能影响血脂的不同因素，将患者分为不同的亚组。与男性相比，糖尿病女性的平均总胆固醇浓度显著更高。作者未发现肥胖和非肥胖糖尿病患者的血脂浓度有显著差异。与无高血压的糖尿病患者相比，高血压糖尿病患者的平均总胆固醇水平和低密度脂蛋白胆固醇水平更高。与接受胰岛素治疗的糖尿病患者相比，使用口服降糖药的患者平均甘油三酯水平显著更高，高密度脂蛋白胆固醇水平更低。在多元逐步回归分析中，甘油三酯与三个独立变量相关：总胆固醇、舒张压，且与高密度脂蛋白胆固醇呈负相关。另一方面，总胆固醇与甘油三酯、高密度脂蛋白胆固醇和每日蛋白尿显著相关。总之，可以说，本研究结果与雷文的X综合征概念一致，然而胆固醇浓度也受蛋白尿影响。
