Nakamura T, Tabeke K, Terada A, Kudoh K, Yamada N, Arai Y, Kikuchi H
Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.
Acta Gastroenterol Belg. 1993 Sep-Dec;56(5-6):326-31.
Short-chain carboxylic acids in the feces of 12 patients with chronic pancreatitis having steatorrhea and 18 healthy subjects were determined by high-performance liquid chromatography. The fecal amount of the patients with chronic pancreatitis was increased to about twice that of the control, and the fat in the feces increased to eight times. The excretion of short-chain carboxylic acids increased to about three times. The short-chain carboxylic acid concentration regarded as derived from protein or amino acid, such as iso-butyrate, isovalerate, and n-valerate, was significantly increased in patients with chronic pancreatitis. From the above results, our data suggest that there is maldigestion of protein besides that of carbohydrate. And we confirmed that these data are an in-vivo illustration of the phenomena which have been studied in-vitro experiments, when fecal bacteria were incubated with peptide or amino acids as a substrate.
采用高效液相色谱法测定了12例患有脂肪泻的慢性胰腺炎患者及18名健康受试者粪便中的短链羧酸。慢性胰腺炎患者的粪便量增加至对照组的约两倍，粪便中的脂肪增加至八倍。短链羧酸的排泄量增加至约三倍。慢性胰腺炎患者中，被认为源自蛋白质或氨基酸的短链羧酸浓度，如异丁酸、异戊酸和正戊酸，显著增加。根据上述结果，我们的数据表明，除了碳水化合物消化不良外，还存在蛋白质消化不良。并且我们证实，当将粪便细菌与肽或氨基酸作为底物进行孵育时，这些数据是体外实验中所研究现象的体内例证。
