Soto J, Sacristan J A, Alsar M J, Fernandez-Viadero C, Verduga R
Clinical Pharmacology Unit, Hospital Santa Cruz, Liencres-Cantabria, Spain.
Acta Haematol. 1993;90(4):195-7. doi: 10.1159/000204457.
We present the case of a woman undergoing treatment with acenocoumarol for deep vein thrombosis, who maintained an international normalized ratio (INR) of between 2.5 and 4 for 2 months. Seven days after the introduction of amoxycillin (500 mg/8 h) for a probable respiratory infection, the patient developed spontaneous bruising, with an INR of 7.1. Treatment with amoxycillin was discontinued, and 3 weeks later the INR had returned to previous values. In this case, the increase in the INR value with associated bruising after the addition of amoxycillin suggests a drug interaction between acenocoumarol and amoxycillin, other possible causes having been eliminated.
我们报告了一例接受醋硝香豆素治疗深静脉血栓形成的女性病例，该患者的国际标准化比值（INR）在2.5至4之间维持了2个月。在因可能的呼吸道感染开始使用阿莫西林（500毫克/8小时）7天后，患者出现自发性瘀伤，INR为7.1。阿莫西林治疗被停用，3周后INR恢复到先前值。在该病例中，添加阿莫西林后INR值升高并伴有瘀伤，这表明醋硝香豆素与阿莫西林之间存在药物相互作用，其他可能的原因已被排除。
