Nygård E, Naesh O, Hindberg I, Valentin N
Department of Anaesthesia, Gentofte Hospital, Denmark.
Acta Anaesthesiol Scand. 1994 Jan;38(1):40-2. doi: 10.1111/j.1399-6576.1994.tb03834.x.
Twelve otherwise healthy male volunteers scheduled for arthroscopy of the knee were studied. The influence in vivo of nitrous oxide (N2O) per se and the addition of a halogenated volatile anaesthetic (halothane or isoflurane) on ADP-induced platelet aggregation and release of beta-thromboglobulin into plasma was evaluated. All measurements were made before surgery. We found that N2O increased platelet aggregation. Adding a halogenated anaesthetic reversed the relative hyperaggregation induced by N2O. The concentrations in plasma of the platelet release product beta thromboglobulin were not influenced by the anaesthetics.
对12名计划进行膝关节镜检查的其他方面健康的男性志愿者进行了研究。评估了一氧化二氮（N₂O）本身以及添加卤代挥发性麻醉剂（氟烷或异氟烷）对ADP诱导的血小板聚集以及β-血小板球蛋白释放到血浆中的体内影响。所有测量均在手术前进行。我们发现N₂O会增加血小板聚集。添加卤代麻醉剂可逆转由N₂O诱导的相对过度聚集。血小板释放产物β-血小板球蛋白的血浆浓度不受麻醉剂影响。
