分泌催乳素的垂体腺瘤患者儿茶酚胺神经元的缺陷。

A defect in catecholamine neurons in patients with prolactin-secreting pituitary adenoma.

作者信息

Van Loon G R

出版信息

Lancet. 1978 Oct 21;2(8095):868-71. doi: 10.1016/s0140-6736(78)91572-6.

Abstract

Although basal plasma concentrations of dopamine, noradrenaline, and adrenaline in patients with prolactin-secreting pituitary adenoma are normal, responses to oral bromocriptine are not. 1 and 2 h after bromocriptine, plasma concentrations of these three catecholamines are decreased in normal men but not in patients with hyperprolactinaemia secondary to prolactin-secreting pituitary adenoma or in normoprolactinaemic patients in whom a pituitary adenoma has been removed. Patients with prolactin-secreting pituitary adenoma probably have a defect in the regulation of brain catecholamine metabolism.

摘要

尽管催乳素分泌型垂体腺瘤患者的多巴胺、去甲肾上腺素和肾上腺素的基础血浆浓度正常，但对口服溴隐亭的反应却不正常。在服用溴隐亭1小时和2小时后，正常男性的这三种儿茶酚胺血浆浓度会降低，但继发于催乳素分泌型垂体腺瘤的高催乳素血症患者或垂体腺瘤已被切除的正常催乳素血症患者则不会。催乳素分泌型垂体腺瘤患者可能在脑儿茶酚胺代谢调节方面存在缺陷。