α-二氢麦角隐亭体内外致突变性评估。
Evaluation of the mutagenicity of a-dihydroergocryptine in vitro and in vivo.
作者信息
Adams K, Allen J A, Brooker P C, Jones E, Proudlock R J, Mailland F, Coppi G
机构信息
Department of Mutagenesis and Cell Biology, Huntingdon Research Centre Limited, Cambridgeshire, England.
出版信息
Arzneimittelforschung. 1993 Dec;43(12):1253-7.
PMID:8141809
Abstract
The mutagenic potential of the ergot alkaloid a-dihydroergocryptine (a-DEC, CAS 14271-05-7) was assessed in a series of 5 assays designed to measure gene mutation, chromosomal damage and primary DNA damage. All tests were carried out in accordance with appropriate EEC and OECD Guidelines. No indications of mutagenic potential were observed in any of the assays.
摘要
通过一系列旨在检测基因突变、染色体损伤和原发性DNA损伤的五项试验，评估了麦角生物碱α-二氢麦角隐亭（α-DEC，CAS 14271-05-7）的致突变潜力。所有试验均按照欧洲经济共同体（EEC）和经济合作与发展组织（OECD）的相关指南进行。在任何一项试验中均未观察到致突变潜力的迹象。
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