Martins A N, Newby N, Doyle T F, Kobrine A I, Ramirez A
J Neurosurg. 1976 Mar;44(3):353-8. doi: 10.3171/jns.1976.44.3.0353.
The hydrogen clearance method was used to measure total and focal cerebral blood flow (CBF) in the monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). Some monkeys also received 0.2 to 1.0 mg/kg phentolamine intracisternally 3 hours after SAH. Results show that SAH did not change cerebrovascular resistance, but as cerebral perfusion pressure decreased, CBF fell transiently. Phentolamine injected intracisternally 3 hours after SAH produced a significant fall in arterial blood pressure; cerebrovascular resistance did not change but CBF decreased significantly. These data indicate that intracisternal phentolamine cannot be considered potentially useful to treat ischemic encephalopathy after SAH.
采用氢清除法在模拟蛛网膜下腔出血（SAH）前后及之后5小时测量猴子的全脑和局部脑血流量（CBF）。部分猴子在SAH后3小时还接受了脑池内注射0.2至1.0mg/kg酚妥拉明。结果显示，SAH并未改变脑血管阻力，但随着脑灌注压降低，CBF短暂下降。SAH后3小时脑池内注射酚妥拉明使动脉血压显著下降；脑血管阻力未改变，但CBF显著降低。这些数据表明，脑池内注射酚妥拉明不能被认为对治疗SAH后的缺血性脑病有潜在作用。
