[Polypharmacotherapy: the risk of developing postoperative hemorrhages].

The impact of polypragmasy on the causes of endogenic heparinemia in the early postoperative period was studied in patients operated on the heart under extracorporeal circulation. It has been found that polypragmasy does not break down the heparin-protamine sulfate complex, but impairs the process of its formation to a certain degree. Ascorbic acid lowers the activity of heparin and hence it may be used as a hemostatic stabilizer during endogenous heparinemia.