Kotova S A, Berezhnaia N M, Belova O B
Eksp Klin Farmakol. 1994 Jan-Feb;57(1):61-3.
Radioisotopic assay has shown that in vitro histamine increases the metabolism of cyclic adenosine monophosphate (cAMP) through H-2 receptors in the peripheral blood lymphocytes of healthy individuals and patients with atopic bronchial asthma. In patients who have asphyxia the histamine-induced stimulation of the activity of cAMP phosphodiesterase metabolizing cAMP is considerably decreased. In is suggested that high cAMP metabolism may be a cause of desensitization of histaminic and adrenergic receptors in atopy whose aggravation is accompanied by histaminemia.
放射性同位素测定表明，在体外，组胺可通过健康个体和特应性支气管哮喘患者外周血淋巴细胞中的H-2受体增加环磷酸腺苷（cAMP）的代谢。在窒息患者中，组胺诱导的代谢cAMP的cAMP磷酸二酯酶活性刺激显著降低。有人认为，高cAMP代谢可能是特应性中组胺能和肾上腺素能受体脱敏的一个原因，其加重伴有组胺血症。
