Padlan E A, Helm B A
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Receptor. 1993 Winter;3(4):325-41.
Models of the lectin-homology domains of the human and murine low-affinity receptors for IgE (Fc epsilon RII/CD23) were built on the basis of sequence similarity with rat mannose-binding protein, the structure of which is known. The sites on Fc epsilon RII/CD23 that are possibly involved in the interaction with IgE and with another ligand, CD21/CR2, are proposed. The models may assist the design of protein engineering experiments for the study of the reactivity of these molecules.
基于与已知结构的大鼠甘露糖结合蛋白的序列相似性，构建了人及小鼠IgE低亲和力受体（FcεRII/CD23）凝集素同源结构域的模型。文中提出了FcεRII/CD23上可能参与与IgE及另一种配体CD21/CR2相互作用的位点。这些模型可能有助于设计蛋白质工程实验来研究这些分子的反应性。
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