Kwong Y L, Pang J, Ching L M, Liu H W, Liang R H, Chan L C
University Department of Medicine, Queen Mary Hospital, Hong Kong.
Cancer Genet Cytogenet. 1994 Feb;72(2):83-5. doi: 10.1016/0165-4608(94)90119-8.
B-cell chronic lymphocytic leukemia (CLL) is a rare disorder in the Chinese population. We evaluated the use of fluorescence in situ hybridization (FISH) with a chromosome 12-specific probe in the detection of trisomy 12 in interphase cell of 19 Chinese CLL patients. FISH successfully detected trisomy 12 in two cases, one of which had normal conventional cytogenetic findings, giving an incidence of 10%. The low incidence of trisomy 12 in our CLL patients may also reflect a biologic difference of this rare disorder in our population, compared to that of the West.
B细胞慢性淋巴细胞白血病（CLL）在中国人群中是一种罕见的疾病。我们评估了使用针对12号染色体的特异性探针进行荧光原位杂交（FISH），以检测19例中国CLL患者间期细胞中的12号染色体三体。FISH成功检测出2例12号染色体三体，其中1例常规细胞遗传学检查结果正常，发生率为10%。与西方人群相比，我们的CLL患者中12号染色体三体的低发生率可能也反映了这种罕见疾病在我们人群中的生物学差异。
