儿童T细胞急性淋巴细胞白血病中的14号染色体倒位（14）（q11q32）
Inversion (14)(q11q32) in childhood T-cell acute lymphoblastic leukemia.
作者信息
Kwong Y L, Shing M K, Wan T M, Yuen P M, Chan A Y, Wong K F, Chan L C
机构信息
University Department of Pathology, Queen Mary Hospital, Hong Kong.
出版信息
Cancer Genet Cytogenet. 1994 Feb;72(2):92-5. doi: 10.1016/0165-4608(94)90121-x.
PMID:8143282
Abstract
Inversion (14)(q11q32) is a common cytogenetic aberration in T-cell chronic lymphoid malignancies but is rare in T-cell acute lymphoblastic leukemia (T-ALL). We describe two cases of childhood T-ALL in which inv(14)(q11q32) was present concomitantly with other karyotypic aberrations typical of T-ALL. The possible significance of inv(14) in these cases is also discussed.
摘要
14号染色体倒位（14）（q11q32）是T细胞慢性淋巴细胞性恶性肿瘤中常见的细胞遗传学异常，但在T细胞急性淋巴细胞白血病（T-ALL）中罕见。我们描述了两例儿童T-ALL病例，其中14号染色体倒位（14）（q11q32）与T-ALL典型的其他核型异常同时存在。还讨论了这些病例中14号染色体倒位的可能意义。
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