熊去氧胆酸可改善大鼠中乙炔雌二醇诱导的胆汁淤积。
Ursodeoxycholic acid improves ethinyl estradiol-induced cholestasis in the rat.
作者信息
Jacquemin E, Dumont M, Mallet A, Erlinger S
机构信息
Unité de Recherches de Physiopathologie Hépatique (Inserm U-24), Hôpital Beaujon, Clichy, France.
出版信息
Eur J Clin Invest. 1993 Dec;23(12):794-802. doi: 10.1111/j.1365-2362.1993.tb00733.x.
The effect of oral chronic administration of ursodeoxycholic acid has been examined in rats with cholestasis induced by ethinyl estradiol. Ursodeoxycholic acid at the dose of 25 mg kg-1 per day during 4 days, did not improve the decrease in basal bile flow and bile acid secretion induced by ethinyl estradiol alone. In contrast, when ursodeoxycholic acid was given at the same dose during 10 days, basal bile flow was significantly improved and basal bile acid secretion was restored to control values. When ursodeoxycholic acid was given at the dose of 500 mg kg-1 per day, basal bile flow and bile acid output were not further improved. However, bile flow and bile acid output under taurocholate infusion were restored to control values. Bile of rats treated with ursodeoxycholic acid was enriched with this bile acid. These results show a significant improvement of ethinyl estradiol-induced cholestasis in rats after chronic administration of ursodeoxycholic acid and support the use of this bile acid in intrahepatic cholestasis in man.
已在乙炔雌二醇诱导胆汁淤积的大鼠中研究了口服熊去氧胆酸的慢性给药效果。每天25 mg/kg剂量的熊去氧胆酸连续给药4天，并未改善仅由乙炔雌二醇诱导的基础胆汁流量和胆汁酸分泌的降低。相反，当熊去氧胆酸以相同剂量连续给药10天时，基础胆汁流量显著改善，基础胆汁酸分泌恢复至对照值。当熊去氧胆酸以每天500 mg/kg的剂量给药时，基础胆汁流量和胆汁酸输出未进一步改善。然而，牛磺胆酸盐输注下的胆汁流量和胆汁酸输出恢复至对照值。用熊去氧胆酸治疗的大鼠胆汁中富含这种胆汁酸。这些结果表明，慢性给予熊去氧胆酸后，大鼠乙炔雌二醇诱导的胆汁淤积有显著改善，并支持在人类肝内胆汁淤积中使用这种胆汁酸。
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