Pesatori A C, Consonni D, Tironi A, Zocchetti C, Fini A, Bertazzi P A
Institute of Occupational Health, Università degli Studi, Milano, Italy.
Int J Epidemiol. 1993 Dec;22(6):1010-3. doi: 10.1093/ije/22.6.1010.
An industrial accident in Seveso, Italy, in 1976, caused contamination of the residential community with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). We investigated cancer occurrence in the first post-accident decade (1977-1986) among nearly 20,000 subjects aged 0-19 years. People who left the area were actively followed with a 99% follow-up rate. For reported cancer cases confirmation was obtained through consultation with original medical records. Two ovarian cancers were observed versus none expected. A suggestive increase was seen for Hodgkin's lymphoma (relative risk [RR] = 2.0; 95% confidence interval [CI] = 0.5-7.6). Myeloid leukaemia showed a clear, but not statistically significant increase (RR = 2.7; 95% CI = 0.7-11.4). The most prominent result concerned thyroid cancer, not just for the magnitude of the increase (two cases, RR = 4.6; 95% CI = 0.6-32.7), but also for its consistency with experimental findings and previous observations in humans. Any conclusive interpretation would be premature because of the short time since initial exposure, ecological definition of exposure status, and limited number of events.
1976年，意大利塞韦索发生一起工业事故，导致当地居民社区被2,3,7,8-四氯二苯并对二恶英（TCDD）污染。我们调查了事故发生后的第一个十年（1977 - 1986年）里近20,000名0至19岁人群中的癌症发病情况。对离开该地区的人群进行了积极随访，随访率达99%。对于报告的癌症病例，通过查阅原始医疗记录进行确认。观察到两例卵巢癌，而预期病例数为零。霍奇金淋巴瘤有提示性增加（相对危险度[RR]=2.0；95%置信区间[CI]=0.5 - 7.6）。髓细胞白血病有明显增加，但无统计学意义（RR = 2.7；95% CI = 0.7 - 11.4）。最显著的结果与甲状腺癌有关，不仅在于增加的幅度（两例，RR = 4.6；95% CI = 0.6 - 32.7），还在于其与实验结果以及先前人类观察结果的一致性。由于自首次接触以来时间较短、暴露状态的生态学定义以及事件数量有限，任何确定性的解释都为时过早。
