Elferink L A, Scheller R H
Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Stanford University Medical Center, CA 94305.
J Cell Sci Suppl. 1993;17:75-9. doi: 10.1242/jcs.1993.supplement_17.11.
The recent identification of novel proteins associated with the membranes of synaptic vesicles has ignited the field of molecular neurobiology to probe the function of these molecules. Evidence is mounting that the vesicle proteins vamp (synaptobrevin), rab3A, synaptophysin, synaptotagmin (p65) and SV2 play an important role in regulated exocytosis, by regulating neurotransmitter uptake, vesicle targeting and fusion with the presynaptic plasma membrane.
最近对与突触小泡膜相关的新蛋白质的鉴定，激发了分子神经生物学领域对这些分子功能的探索。越来越多的证据表明，小泡蛋白vamp（突触小泡蛋白）、rab3A、突触素、突触结合蛋白（p65）和SV2通过调节神经递质摄取、小泡靶向以及与突触前质膜的融合，在调节性胞吐作用中发挥重要作用。
