局部应用甲硝唑作为龈下刮治术的辅助治疗手段用于慢性牙周炎的治疗
Topical metronidazole as an adjunct to subgingival debridement in the treatment of chronic periodontitis.
作者信息
Hitzig C, Charbit Y, Bitton C, Fosse T, Teboul M, Hannoun L, Varonne R
机构信息
Department of Periodontology, School of Dentistry, University of Nice, France.
出版信息
J Clin Periodontol. 1994 Feb;21(2):146-51. doi: 10.1111/j.1600-051x.1994.tb00293.x.
The purpose of this study was to evaluate the clinical effects of a single application of a 5% metronidazole collagen device in periodontal pockets deeper than 5 mm, in association with debridement and without reinforcement of home care and hygiene as practiced by the patient at any time. Pocket depth, attachment level, bleeding on probing, gingival index and plaque index were assessed at baseline, and on days 15, 30 and 90. Analysis of data from 28 patients indicated that both debridement and metronidazole therapy decreased pocket depth, bleeding on probing and gingival index, but results were significantly better with metronidazole. These results indicate that topical metronidazole provides an effective adjunctive treatment of advanced periodontitis.
本研究的目的是评估单次应用5%甲硝唑胶原装置对深度超过5mm的牙周袋的临床效果，该应用与清创术联合进行，且患者在任何时候均未加强家庭护理和口腔卫生。在基线时以及第15、30和90天评估牙周袋深度、附着水平、探诊出血、牙龈指数和菌斑指数。对28例患者的数据分析表明，清创术和甲硝唑治疗均能降低牙周袋深度、探诊出血和牙龈指数，但甲硝唑治疗的效果明显更好。这些结果表明，局部应用甲硝唑为晚期牙周炎提供了一种有效的辅助治疗方法。
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