Elavarasu Sugumari, Suthanthiran Thanga Kumaran, Naveen Devisree
Department of Periodontics, JKK Nattaraja Dental College, Komarapalayam, Tamil Nadu, India.
J Pharm Bioallied Sci. 2012 Aug;4(Suppl 2):S248-51. doi: 10.4103/0975-7406.100225.
Periodontitis is an inflammatory disease of the supporting tissues of the teeth, caused by a group of specific microorganisms. Aggressive forms of periodontitis can be localized or generalized. The concept that localized problem sites may be treated by local drug delivery appears attractive as the antimicrobial agent is delivered within periodontal pockets and the therapy is targeted on specific pathogenic microorganisms. Periodontitis can result in bone resorption creating bony defects, which may cause tooth loss. Various drugs have been studied using local delivery to improve the periodontal health and to achieve periodontal regeneration. Local delivery of antimicrobial agents using controlled release systems should be considered as adjunctive to mechanical debridement for the treatment of localized forms of periodontal destruction. Pharmacological agents offer great promise in this direction. Simvastatin, used for the treatment of hypercholesterolemia, is a universally accepted and relatively inexpensive drug. Local application of simvastatin has been shown to stimulate bone formation in rodents both in vitro and in vivo and in human periodontal ligament cells in vitro. This article reviews the effects of simvastatin as a local delivery and examines its potential role in periodontal regenerative therapy.
牙周炎是一种由一组特定微生物引起的牙齿支持组织的炎症性疾病。侵袭性牙周炎可分为局限性或广泛性。局部问题部位可通过局部给药治疗的概念似乎很有吸引力，因为抗菌剂是在牙周袋内递送的，并且该疗法针对特定的致病微生物。牙周炎可导致骨吸收，形成骨缺损，这可能导致牙齿脱落。已经研究了使用局部递送各种药物来改善牙周健康并实现牙周再生。使用控释系统局部递送抗菌剂应被视为治疗局限性牙周破坏的机械清创术的辅助手段。药物制剂在这方面有很大的前景。用于治疗高胆固醇血症的辛伐他汀是一种普遍接受且相对便宜的药物。辛伐他汀的局部应用已被证明在体外和体内均可刺激啮齿动物的骨形成，并且在体外可刺激人牙周膜细胞的骨形成。本文综述了辛伐他汀作为局部递送的作用，并探讨了其在牙周再生治疗中的潜在作用。
