[α重链病——地中海淋巴瘤]

[Alpha-heavy chain disease--Mediterranean lymphoma].

作者信息

Kaufmann H P, Schmitt W, Seib H J

机构信息

I. Med. Abteilung, Städt. Krankenhaus München-Neuperlach, Akademisches Lehrkrankenhaus.

出版信息

Leber Magen Darm. 1994 Feb;24(1):32-5.

PMID:8145624

Abstract

For 6 months diarrhea and weight loss of 30 kg occurred in a 28 year old man from the Emirates. The endoscopic examination suggested a small intestinal lymphoma affecting the entire small intestine, which was confirmed by biopsies, immunohistochemistry, immunologic proof of monoclonal IgA-gammopathy in serum and urine. The patient acquired a malignant MALT-lymphoma of B-cell-type, a alpha-Heavy Chain Disease, synonym mediterranean lymphoma or immunoproliferative small intestinal disease (IPSID), stage A with transition in stage B. The patient was treated with ciprofloxacine in association with metronidazole with no influence of the course of the disease.

摘要

一名来自阿联酋的28岁男子出现腹泻6个月，体重减轻30公斤。内镜检查提示小肠淋巴瘤累及整个小肠，活检、免疫组化、血清和尿液中单克隆IgA-γ病的免疫学证据证实了这一点。该患者患上了B细胞型恶性黏膜相关淋巴组织淋巴瘤，即α重链病，又称地中海淋巴瘤或免疫增殖性小肠疾病（IPSID），处于A期并向B期转变。该患者接受了环丙沙星联合甲硝唑治疗，但疾病进程未受影响。