Brodin B, Rytved K A, Nielsen R
Laboratory of Biological Chemistry A, August Krogh Institute, University of Copenhagen, Denmark.
Pflugers Arch. 1994 Jan;426(1-2):171-3. doi: 10.1007/BF00374685.
Cytosolic calcium ([Ca2+]i) has been suggested as a key modulator in the regulation of active sodium transport across electrically "tight" (high resistance) epithelia. In this study we investigated the effects of calcium on cellular electrophysiological parameters in a classical model tissue, the frog skin. [Ca2+]i was measured with fura-2 in an epifluorescence microscope setup. An inhibition of basolateral potassium permeability was observed when cytosolic calcium was increased. This inhibition was reversible upon removal of calcium from the serosal solution.
