• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

7α-甲基-19-去甲睾酮:一种用于替代疗法的理想雄激素。

7 alpha-Methyl-19-nortestosterone: an ideal androgen for replacement therapy.

作者信息

Sundaram K, Kumar N, Bardin C W

机构信息

Center for Biomedical Research, Population Council, New York, New York 10021.

出版信息

Recent Prog Horm Res. 1994;49:373-6. doi: 10.1016/b978-0-12-571149-4.50027-1.

DOI:10.1016/b978-0-12-571149-4.50027-1
PMID:8146434
Abstract

MENT is a synthetic androgen which cannot be 5 alpha-reduced. Therefore, relative to T, its stimulatory action on the prostate is lower than that on the muscle and pituitary. Like T, MENT undergoes enzymatic aromatization to an estrogen. We conclude that the use of MENT instead of T for androgen replacement therapy could have health-promoting effects by reducing the occurrence of prostate disease.

摘要

MENT是一种不能进行5α还原的合成雄激素。因此,相对于睾酮(T),它对前列腺的刺激作用低于对肌肉和垂体的刺激作用。与T一样,MENT会通过酶促反应芳香化为雌激素。我们得出结论,用MENT替代T进行雄激素替代疗法可能通过减少前列腺疾病的发生而产生促进健康的效果。

相似文献

1
7 alpha-Methyl-19-nortestosterone: an ideal androgen for replacement therapy.7α-甲基-19-去甲睾酮:一种用于替代疗法的理想雄激素。
Recent Prog Horm Res. 1994;49:373-6. doi: 10.1016/b978-0-12-571149-4.50027-1.
2
The biological activity of 7 alpha-methyl-19-nortestosterone is not amplified in male reproductive tract as is that of testosterone.7α-甲基-19-去甲睾酮的生物活性在雄性生殖道中不像睾酮那样被放大。
Endocrinology. 1992 Jun;130(6):3677-83. doi: 10.1210/endo.130.6.1597164.
3
Induction of male sexual behavior in the rat by 7 alpha-methyl-19-nortestosterone, an androgen that does not undergo 5 alpha-reduction.7α-甲基-19-去甲睾酮(一种不会发生5α-还原的雄激素)诱导大鼠的雄性性行为。
Biol Reprod. 1993 Sep;49(3):577-81. doi: 10.1095/biolreprod49.3.577.
4
The potent synthetic androgens, dimethandrolone (7α,11β-dimethyl-19-nortestosterone) and 11β-methyl-19-nortestosterone, do not require 5α-reduction to exert their maximal androgenic effects.强效合成雄激素,二甲睾酮(7α,11β-二甲基-19-去甲睾酮)和 11β-甲基-19-去甲睾酮,不需要 5α-还原就可以发挥其最大的雄激素作用。
J Steroid Biochem Mol Biol. 2010 Oct;122(4):212-8. doi: 10.1016/j.jsbmb.2010.06.009. Epub 2010 Jun 25.
5
Feedback regulation of gonadotropins by androgens in rats: is 5 alpha-reduction involved?雄激素对大鼠促性腺激素的反馈调节:是否涉及5α-还原作用?
J Steroid Biochem Mol Biol. 1995 Jan;52(1):105-12. doi: 10.1016/0960-0760(94)00150-k.
6
[Anabolic activity of 9, 10-dehydro-19-nortestosterone derivatives].[9,10-脱氢-19-去甲睾酮衍生物的合成代谢活性]
Probl Endokrinol (Mosk). 1974 Jul-Aug;20(4):83-8.
7
Aromatization of 7 alpha-methyl-19-nortestosterone by human placental microsomes in vitro.人胎盘微粒体体外对7α-甲基-19-去甲睾酮的芳香化作用。
J Steroid Biochem Mol Biol. 1994 Feb;48(2-3):297-304. doi: 10.1016/0960-0760(94)90160-0.
8
Prostate-sparing effects in primates of the potent androgen 7alpha-methyl-19-nortestosterone: a potential alternative to testosterone for androgen replacement and male contraception.强效雄激素7α-甲基-19-去甲睾酮对灵长类动物的前列腺保护作用:雄激素替代和男性避孕中睾酮的潜在替代品。
J Clin Endocrinol Metab. 1998 Dec;83(12):4212-9. doi: 10.1210/jcem.83.12.5324.
9
Dimethandrolone (7alpha,11beta-dimethyl-19-nortestosterone) and 11beta-methyl-19-nortestosterone are not converted to aromatic A-ring products in the presence of recombinant human aromatase.在重组人芳香化酶存在的情况下,二甲双氢睾酮(7α,11β-二甲基-19-去甲睾酮)和11β-甲基-19-去甲睾酮不会转化为芳香化A环产物。
J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):214-22. doi: 10.1016/j.jsbmb.2007.11.009.
10
Distribution, metabolism and excretion of a synthetic androgen 7alpha-methyl-19-nortestosterone, a potential male-contraceptive.一种潜在的男性避孕药——合成雄激素7α-甲基-19-去甲睾酮的分布、代谢及排泄
Steroids. 2009 Jan;74(1):121-31. doi: 10.1016/j.steroids.2008.09.012. Epub 2008 Oct 17.