Abdulkadyrov K M, Bessmel'tsev S S
Ter Arkh. 1993;65(12):70-2.
A clinical trial of a new drug bonefos (Leiras, Finland) in 13 patients with multiple myeloma confirmed its potent analgetic effect. Alleviation of ostealgia was seen as early as the treatment day 5-7. The drug inhibits the progression of skeletal tumor growth, reduces the frequency of bone fractures, normalizes calcium concentrations in the blood and urine. Side effects such as nausea and short-term epigastric pains occurred in 23% and 15.38% of the patients, respectively.
