Sakai K, Okuyama H, Shimazaki H, Katagiri M, Torii S, Matsushita T, Baba S
Faculty of Pharmaceutical Sciences, Nagoya City University.
Arerugi. 1994 Jan;43(1):37-43.
The proportions of linoleic acid in total plasma lipids and phospholipids were significantly greater and those of oleic acid were lower in pre-puberal and puberal atopic patients as compared with age-matched healthy controls. The n-3/n-6 fatty acid ratio of the triacylglycerol fraction was also lower in atopic patients. However, no significant decreases in the proportions of dihomo-gamma-linolenic acid and arachidonic acid were observed in plasma lipids of atopic patients, suggesting that delta 6-desaturase activity is not impaired in atopic patients. We provide an explanation for the beneficial effects of raising the n-3/n-6 ratio of dietary oils in the context of suppressing allergic hyper-reactivity in humans.
与年龄匹配的健康对照组相比，青春期前和青春期特应性患者血浆总脂质和磷脂中亚油酸的比例显著更高，油酸的比例更低。特应性患者三酰甘油部分的n-3/n-6脂肪酸比值也更低。然而，在特应性患者的血浆脂质中未观察到二高-γ-亚麻酸和花生四烯酸比例的显著降低，这表明特应性患者的δ6-去饱和酶活性未受损。我们针对在抑制人类过敏超敏反应的背景下提高食用油n-3/n-6比值的有益作用给出了解释。
