Bo P, Murelli R, Soragna D, Ferrandi D, Savoldi F
Istituto Neurologico C. Mondino Università di Pavia.
Boll Soc Ital Biol Sper. 1993 Jun;69(6):381-6.
In this study we investigated the central effects of adinazolam, a triazolobenzodiazepine, by means of neurophysiological techniques (electroencephalogram, EEG, and quantified analysis of EEG, QEEG). The drug has been administered at the doses of 0.1-1-10 mg/kg i.v. The evaluation of the data obtained by QEEG has demonstrated that this substance acts on the central nervous system. Particularly we observed that the drug at the middle and high doses caused an increase of the "slow waves sleep" EEG pattern. This preclinical study has shown that adinazolam possesses a neuropharmacological profile similar to that of atypical antidepressive and/or anxiolytic drugs.
在本研究中，我们借助神经生理学技术（脑电图，EEG，以及脑电图定量分析，QEEG）研究了三唑并苯二氮䓬类药物阿地唑仑的中枢效应。该药物已通过静脉注射给予了0.1 - 1 - 10 mg/kg的剂量。对QEEG所获数据的评估表明，这种物质作用于中枢神经系统。特别地，我们观察到中高剂量的该药物会导致“慢波睡眠”EEG模式增加。这项临床前研究表明，阿地唑仑具有与非典型抗抑郁和/或抗焦虑药物相似的神经药理学特征。
