Shimizu M, Takazakura E, Hayakawa H, Kawai K, Muramoto S
Ann Endocrinol (Paris). 1975 Nov-Dec;36(6):317-20.
After the administration of TRH the hyperresponse of TSH was observed in the non-treated addisonians and the normal response in the treated addisonians. These reulsts are inverted to those found in the patients of hyperadrenocorticism or treated with corticoid. This hyperresponse of TSH to TRH is due to the lack of corticoid and makes us suppose that the corticoid controls the TRH-TSH system as well as the CRF-ACTH system.
给予促甲状腺激素释放激素(TRH)后,未治疗的艾迪生病患者出现促甲状腺激素(TSH)的高反应,而接受治疗的艾迪生病患者出现正常反应。这些结果与皮质醇增多症患者或接受皮质类固醇治疗的患者的结果相反。TSH对TRH的这种高反应是由于缺乏皮质类固醇,这使我们推测皮质类固醇不仅控制促肾上腺皮质激素释放因子(CRF)-促肾上腺皮质激素(ACTH)系统,还控制TRH-TSH系统。