Yamamoto N, Takahashi H E, Tanizawa T, Fujimoto R, Hara T, Tanaka S
Department of Orthopaedic Surgery, School of Medicine, Niigata University, Japan.
Bone Miner. 1993 Dec;23(3):333-42. doi: 10.1016/s0169-6009(08)80107-9.
Human PTH(1-34) has been recognized for its marked anabolic effect on bone, but that effect has been reported to be lost after cessation of PTH treatment. The objective of this study was to determine the fate of hPTH-stimulated bone and whether this anabolic effect of PTH could be maintained by daily exercise. Eleven-week-old Sprague-Dawley rats were ovariectomized (OVX) and human PTH(1-34) (30 micrograms/kg) was injected subcutaneously three times per week for 12 weeks beginning one week after surgery. After the cessation of PTH treatment, treadmill exercises were performed for 8 weeks (15.7 m/min, 1 h/day, 5 days/week). The results of histomorphometric assessment in the proximal tibial metaphysis demonstrated that hPTH treatment partially prevented OVX-induced cancellous bone loss. Eight weeks following the cessation of PTH treatment, PTH-stimulated bone mass went back to the OVX control level. Daily exercise did maintain PTH-stimulated bone mass; however, this exercise did not increase the bone mass in PTH-untreated OVX rats.
人甲状旁腺激素（1-34）因其对骨骼具有显著的合成代谢作用而被认可，但据报道，在停止甲状旁腺激素治疗后这种作用会消失。本研究的目的是确定甲状旁腺激素刺激后的骨骼命运，以及甲状旁腺激素的这种合成代谢作用是否可以通过日常运动得以维持。11周龄的斯普拉格-道利大鼠接受卵巢切除术（OVX），术后1周开始，每周皮下注射3次人甲状旁腺激素（1-34）（30微克/千克），持续12周。在停止甲状旁腺激素治疗后，进行8周的跑步机运动（15.7米/分钟，每天1小时，每周5天）。胫骨近端干骺端组织形态计量学评估结果表明，甲状旁腺激素治疗部分预防了卵巢切除引起的松质骨丢失。停止甲状旁腺激素治疗8周后，甲状旁腺激素刺激的骨量恢复到卵巢切除对照组水平。日常运动确实维持了甲状旁腺激素刺激的骨量；然而，这种运动并没有增加未接受甲状旁腺激素治疗的卵巢切除大鼠的骨量。
