Lee P A
Department of Pediatrics, University of Pittsburgh School of Medicine, Pa.
Arch Pediatr Adolesc Med. 1994 Apr;148(4):369-76. doi: 10.1001/archpedi.1994.02170040035006.
It is necessary not only to perform laboratory tests for the correct diagnosis of children with precocious puberty, but also to monitor laboratory tests to ensure adequacy of therapy. Careful laboratory testing is a requisite in the differentiation of central from peripheral precocious puberty. It is also required to determine whether the patient who presents with early physical changes of pubertal development with peripheral precocious puberty has evidence of pubertal hormonal secretion. The most useful single test is gonadotropin-releasing hormone (gonadorelin) stimulation of luteinizing hormone release. The same stimulation test is also indicated to verify the adequacy of suppression of gonadotropin secretion among patients with central precocious puberty who are being treated with gonadotropin-releasing hormone analogue. It is necessary to know which gonadotropin assay is being used and the range of normal levels to correctly interpret the tests.
不仅有必要进行实验室检查以正确诊断性早熟儿童，还需要监测实验室检查以确保治疗的充分性。仔细的实验室检查是区分中枢性性早熟和外周性性早熟的必要条件。对于表现为外周性性早熟青春期发育早期身体变化的患者，还需要确定其是否有青春期激素分泌的证据。最有用的单项检查是促性腺激素释放激素（戈那瑞林）刺激促黄体生成素释放。对于正在接受促性腺激素释放激素类似物治疗的中枢性性早熟患者，同样的刺激试验也用于验证促性腺激素分泌抑制的充分性。有必要了解所使用的促性腺激素测定方法以及正常水平范围，以便正确解读检查结果。
