Kelley J L, Burke T W, Lichtiger B, Dupuis J F
Department of Gynecology, University of Texas M.D. Anderson Cancer Center, Houston.
J Am Coll Surg. 1994 Apr;178(4):397-400.
Difficult pelvic operations for malignancy or complex benign conditions can be associated with extensive blood loss. Religious beliefs that preclude transfusion and the known risks of homologous blood have prompted investigators to seek alternatives to transfusion. We used the Haemonetics-V50 Cell Separator (Haemonetics Corporation) to provide for extracorporeal circulation of the patient's own blood with associated normovolemic hemodilution as a means of conserving blood during operations. This technique was used in eight patients undergoing extensive pelvic operations. The procedure was accepted by Jehovah's Witnesses and was well tolerated by all patients. Estimated blood loss ranged from 75 to 2,000 milliliters. One instance of mild intraoperative disseminated intravascular coagulation was encountered. Two patients were given homologous transfusions. While clinical judgment is necessary to determine the safety of complicated operations, this technique is useful in expanding surgical options for some patients who object to blood transfusion.
针对恶性肿瘤或复杂良性疾病的困难盆腔手术可能会导致大量失血。宗教信仰禁止输血以及已知的同源血风险促使研究人员寻求输血的替代方法。我们使用Haemonetics-V50细胞分离器（Haemonetics公司）为患者自身血液提供体外循环，并进行相关的等容血液稀释，以此作为手术中保存血液的一种手段。该技术用于8例接受广泛盆腔手术的患者。该程序得到了耶和华见证人的认可，所有患者均耐受良好。估计失血量在75至2000毫升之间。术中遇到1例轻度弥散性血管内凝血。2例患者接受了同源输血。虽然确定复杂手术的安全性需要临床判断，但该技术对于扩大一些反对输血患者的手术选择是有用的。
