Cui L, Hasegawa R, Zajdela F, Puapairoj P, Shirai T, Ito N
First Department of Pathology, Nagoya City University Medical School, Japan.
Cancer Lett. 1994 Jan 30;76(2-3):161-6. doi: 10.1016/0304-3835(94)90393-x.
Among the nitro-naphthofurans, 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000) has proved to be a very potent mutagen that causes sarcomas at the subcutaneous injection site and carcinomas in the forestomach after p.o. administration. In the present study, possible promoting activity for diethylnitrosamine (200 mg/kg, i.p.)-initiated liver carcinogenesis was assessed in rats. R7000 dissolved in 5% ethanol solution at doses of 10 or 50 mg/l given as the drinking water for 6 weeks did not enhance development of pre-neoplastic glutathione S-transferase placental form positive foci. Thus, it was concluded that R7000 may not be carcinogenic for the rat liver under the present experimental conditions.
在硝基萘并呋喃类化合物中，7-甲氧基-2-硝基萘并[2,1-b]呋喃（R7000）已被证明是一种非常强效的诱变剂，皮下注射该物质会导致注射部位出现肉瘤，口服给药后会导致前胃出现癌。在本研究中，评估了R7000对经腹腔注射给予200 mg/kg二乙基亚硝胺引发的大鼠肝癌发生的潜在促进活性。将R7000溶解于5%乙醇溶液中，以10或50 mg/l的剂量作为饮用水给予大鼠6周，结果发现其并未增强癌前谷胱甘肽S-转移酶胎盘型阳性病灶的发展。因此，得出结论，在当前实验条件下，R7000可能对大鼠肝脏无致癌性。
