Abe K, Saito H
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Eur J Pharmacol. 1994 Jan 14;251(2-3):295-8. doi: 10.1016/0014-2999(94)90412-x.
The effect of 2-amino-3-phosphonopropionate (AP3), a metabotropic glutamate receptor antagonist, on long-term potentiation (LTP) of evoked potentials in the dentate gyrus was investigated using anesthetized rats. Intracerebroventricular injection of AP3 (50 nmol) prior to application of tetanic stimulation did not significantly affect LTP induced by 100-pulse, 100-Hz tetanus, but inhibited the formation of LTP by weaker tetanus (30 pulses at 60 Hz). When AP3 was injected after tetanus, it did not significantly affect the established LTP. These results suggest that metabotropic glutamate receptors play a role in facilitation of the formation of LTP in the dentate gyrus in vivo.
使用麻醉大鼠研究了代谢型谷氨酸受体拮抗剂2-氨基-3-膦酰丙酸（AP3）对齿状回诱发电位长时程增强（LTP）的影响。在强直刺激施加前脑室内注射AP3（50 nmol）对100次脉冲、100 Hz强直刺激诱导的LTP无显著影响，但抑制较弱强直刺激（60 Hz，30次脉冲）诱导的LTP形成。当在强直刺激后注射AP3时，对已建立的LTP无显著影响。这些结果表明，代谢型谷氨酸受体在体内促进齿状回LTP形成中发挥作用。
