偏头痛：血小板对前列腺素E1（PGE1）不敏感的可能作用。
Migraine: possible role of platelet insensitivity to prostaglandin E1 (PGE1).
作者信息
Cerneca F, de Luyk S, Radillo O, Simeone R, Mangiarotti M
机构信息
Clinical Pathology Laboratory Haemostasis Service, Pediatric Hospital Burlo Garofolo, Trieste, Italy.
出版信息
Funct Neurol. 1993 Nov-Dec;8(6):403-8.
Platelet aggregation inhibition, induced by prostaglandin E1 (PGE1), was evaluated in 38 patients affected by migraine. Our data indicate a complete insensitivity to PGE1 in these subjects. The insensitivity to PGE1 leads to decreased cyclic-AMP (cAMP) levels, determining an imbalance in the inhibitory mechanism. From this observation we can suppose that the decreased affinity of PGE1-receptors, causing decreased cAMP levels, may be involved in pathogenesis of migraine.
在38例偏头痛患者中评估了前列腺素E1（PGE1）诱导的血小板聚集抑制作用。我们的数据表明这些受试者对PGE1完全不敏感。对PGE1的不敏感导致环磷酸腺苷（cAMP）水平降低，从而导致抑制机制失衡。从这一观察结果我们可以推测，PGE1受体亲和力降低导致cAMP水平下降，可能与偏头痛的发病机制有关。
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