[人类瘢痕中的胶原蛋白多态性]

[Collagen polymorphism in human scars].

作者信息

Bazin S, Bailey A, Le Lous M, Nicolétis C, Delaunay A

出版信息

C R Acad Hebd Seances Acad Sci D. 1975 Nov 10;281(19):1447-9.

Abstract

Collagen similar to the collagen found in embryonic skin (same intermolecular cross-links and same structure of the polypeptide chains) is synthesized in young human scars. Later on, in normal scars, this collagen is replaced by the collagen of adult skin progressively. In contrast, in hypertrophic scars, a high proportion of collagen of "embryonic" type is present permanently. In granulation tissues of chronic inflammation, experimentally developed in rats, similar "embryonic" collagen has been found ; these granuloma are proposed as a model in laboratory animals of human hypertrophic scars.

摘要

在年轻人类瘢痕中合成的胶原蛋白与胚胎皮肤中发现的胶原蛋白相似（分子间交联相同，多肽链结构相同）。后来，在正常瘢痕中，这种胶原蛋白会逐渐被成人皮肤的胶原蛋白所取代。相比之下，在增生性瘢痕中，高比例的“胚胎”型胶原蛋白会永久存在。在大鼠实验性诱导产生的慢性炎症肉芽组织中，也发现了类似的“胚胎”胶原蛋白；这些肉芽肿被作为人类增生性瘢痕的实验动物模型。