乳腺癌的遗传学
The genetics of breast cancer.
作者信息
Morrison B W
机构信息
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts.
出版信息
Hematol Oncol Clin North Am. 1994 Feb;8(1):15-27.
PMID:8150776
Abstract
Some of the genetic abnormalities that give rise to human breast cancer have been identified. This article reviews the biology of the oncogenes c-myc and neu and the antioncogene p53. Data supporting the role of these genes in the pathogenesis of human breast cancer are reviewed. Potential diagnostic and therapeutic applications that have developed out of our understanding of the molecular genetics of breast cancer are also discussed.
摘要
一些导致人类乳腺癌的基因异常已被识别出来。本文综述了癌基因c-myc和neu以及抗癌基因p53的生物学特性。对支持这些基因在人类乳腺癌发病机制中作用的数据进行了综述。还讨论了基于我们对乳腺癌分子遗传学的理解而开发出的潜在诊断和治疗应用。
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