地昔帕明对心脏自主神经控制的影响。
Effects of desipramine on autonomic control of the heart.
作者信息
Walsh B T, Giardina E G, Sloan R P, Greenhill L, Goldfein J
机构信息
Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY.
出版信息
J Am Acad Child Adolesc Psychiatry. 1994 Feb;33(2):191-7. doi: 10.1097/00004583-199402000-00006.
OBJECTIVE
To assess the effects of desipramine (DMI) on autonomic control of the heart.
METHODS
Blood pressure, RR interval (the time between successive heart beats), and RR interval variability, a noninvasive measure of autonomic control of the heart, were assessed in 13 subjects younger than 30 years old.
RESULTS
DMI treatment was associated with an increase in blood pressure, a decrease in RR interval, and a decline in low and high frequency RR interval variability.
CONCLUSIONS
These preliminary data suggest that, in young people, DMI treatment produces a substantial decrease in parasympathetic input to the heart and an increase in the ratio of sympathetic to parasympathetic input, changes that in certain circumstances have been associated with an increased risk of arrhythmia. In exploring the cardiac effects of the tricyclic antidepressants (TCAs) in young people, the impact of TCAs on autonomic input to the heart should be examined.
目的
评估去甲丙咪嗪（DMI）对心脏自主神经控制的影响。
方法
对13名年龄小于30岁的受试者进行血压、RR间期（连续心跳之间的时间）以及RR间期变异性（一种评估心脏自主神经控制的非侵入性指标）的评估。
结果
DMI治疗与血压升高、RR间期缩短以及低频和高频RR间期变异性降低有关。
结论
这些初步数据表明，在年轻人中，DMI治疗会使心脏的副交感神经输入大幅减少，交感神经与副交感神经输入的比例增加，在某些情况下，这些变化与心律失常风险增加有关。在探究三环类抗抑郁药（TCA）对年轻人心脏的影响时，应检查TCA对心脏自主神经输入的影响。
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