一名初发急性淋巴细胞白血病患者的t(14;18)与t(8;9)相关。
The t(14;18) in a patient with de novo acute lymphoblastic leukemia is associated with t(8;9).
作者信息
Lillington D M, Monard S, Johnson P W, Evans M L, Kearney L U, Lister T A, Young B D, Gibbons B
机构信息
ICRF Department of Medical Oncology, St Bartholomew's Hospital, London, UK.
出版信息
Leukemia. 1994 Apr;8(4):560-3.
Cytogenetic analysis of a bone marrow aspirate from a patient with acute lymphoblastic leukemia (ALL) revealed the presence of a complex karyotype containing the translocation, t(14;18)(q32;q21). Further investigations using fluorescence in situ hybridization (FISH) allowed the characterization of an additional translocation, t(8;9)(q24;p1?). The association of t(14;18)(q32;q21) and t(8;9)(q24;p13) has recently been described in two patients with de novo ALL (Nacheva et al. Blood 1993;82:231-240) and this report supports these findings.
对一名急性淋巴细胞白血病（ALL）患者的骨髓穿刺液进行细胞遗传学分析，发现存在一种复杂核型，其中包含易位t(14;18)(q32;q21)。使用荧光原位杂交（FISH）进行的进一步研究确定了另一种易位t(8;9)(q24;p13)。最近在两名新发ALL患者中描述了t(14;18)(q32;q21)和t(8;9)(q24;p13)的关联（Nacheva等人，《血液》1993年；82:231 - 240），本报告支持了这些发现。
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