Friborg J, Yao X J, Boisvert F, Garzon S, Cohen E A
Departement de Microbiologie et Immunologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada.
Leukemia. 1994 Apr;8 Suppl 1:S156-62.
The human immunodeficiency virus type-1 (HIV-1) encoded Vpu protein facilitates the release of budding virions from the surface of infected cells and delays the rate of syncytium formation of the virus. Furthermore, Vpu induces rapid degradation of nascent CD4 molecules that are retained in the endoplasmic reticulum by the formation of gp160-CD4 complexes. Currently, little is known of the precise mechanism(s) by which Vpu function. Whether or not these different events are related remain unclear. In this report, we describe our recent structure/function studies on vpu suggesting that the protein may have independent biological activities during the HIV-1 infection.
1型人类免疫缺陷病毒（HIV-1）编码的Vpu蛋白有助于从受感染细胞表面释放出芽的病毒粒子，并延缓病毒合胞体的形成速率。此外，Vpu通过形成gp160-CD4复合物诱导在内质网中滞留的新生CD4分子快速降解。目前，对于Vpu发挥功能的精确机制知之甚少。这些不同事件是否相关仍不清楚。在本报告中，我们描述了我们最近对vpu的结构/功能研究，表明该蛋白在HIV-1感染过程中可能具有独立的生物学活性。
