Swain S M, Honig S F
Lombardi Cancer Research Center, Department of Medicine, Washington, DC 20007.
Med Pediatr Oncol. 1994;22(6):370-4. doi: 10.1002/mpo.2950220603.
Eighteen patients (17 evaluable for response) with metastatic breast cancer were treated with mitoxantrone 10 mg/m2 day 1, followed by 5-fluorouracil 375 mg/m2 day 1-5, and high-dose leucovorin 500 mg/m2 day 1-5 given every 28 days. There was one complete and four partial responses for an objective response rate of 30% and 41% stable disease. The major toxicities were hematologic and gastrointestinal. This regimen has activity in metastatic breast cancer comparable to conventional and/or standard chemotherapy regimens for advanced disease.
18例转移性乳腺癌患者（17例可评估疗效）接受如下治疗：米托蒽醌10 mg/m²，第1天使用；随后5-氟尿嘧啶375 mg/m²，第1 - 5天使用；高剂量亚叶酸钙500 mg/m²，第1 - 5天使用，每28天重复一次。有1例完全缓解和4例部分缓解，客观缓解率为30%，疾病稳定率为41%。主要毒性反应为血液学和胃肠道反应。该方案治疗转移性乳腺癌的活性与晚期疾病的传统和/或标准化疗方案相当。
