Dignac M, Gabaig A M, Cambus J P, Boneu B
Laboratoire d'Hémostase, Hôpital de Purpan, Toulouse, France.
Nouv Rev Fr Hematol (1978). 1994;35(6):545-9.
Some commercially available chronometric assays are influenced by the residual antithrombin activity of low molecular weight heparins (LMWH) and they underestimate the ex vivo anti Xa activity. We have evaluated a new kit (Staclot-Heparin) highly specific for the anti Xa activity of LMWH. A comparison with the results given by a reference chromogenic method (Stachrom-Heparin) indicates a very good correlation between the 2 assays (r = 0.95, n = 59). This new assay is not influenced by vitamin K antagonist treatments. Clinical biologists now have the possibility of determining the anti Xa activity generated by LMWH easily and accurately, using a chronometric assay.
一些市售的计时测定法会受到低分子量肝素（LMWH）残留抗凝血酶活性的影响，从而低估体外抗Xa活性。我们评估了一种对LMWH抗Xa活性具有高度特异性的新试剂盒（Staclot - 肝素）。与参考显色法（Stachrom - 肝素）给出的结果进行比较表明，这两种测定法之间具有非常好的相关性（r = 0.95，n = 59）。这种新的测定法不受维生素K拮抗剂治疗的影响。临床生物学家现在有可能使用计时测定法轻松、准确地测定LMWH产生的抗Xa活性。
