Rowland N E
Department of Psychology, University of Florida, Gainesville 32611-2065.
Physiol Behav. 1994 Feb;55(2):201-7. doi: 10.1016/0031-9384(94)90124-4.
Tolerance to the anorectic effect of dexfenfluramine (DFEN) is shown in rats treated either chronically with low doses or once with a high dose of the agent. Rats given DFEN regimens that result in complete loss of DFEN anorexia showed no change in the anorexia caused by peripheral injection of cholecystokinin (CCK). The orexigenic effects of metergoline and neuropeptide Y were also unaltered as a function of DFEN pretreatment. Both the magnitude and duration of tolerance to a test dose of DFEN seemed to depend, in part, upon contingent (situational) factors, and were independent of whether brain serotonin (5-HT) measures were either unaffected or decreased by the DFEN pretreatment (low and high doses, respectively).
低剂量长期给药或高剂量单次给药的大鼠对右芬氟拉明（DFEN）的厌食作用产生耐受性。给予导致DFEN厌食完全消失的给药方案的大鼠，外周注射胆囊收缩素（CCK）引起的厌食无变化。甲麦角林和神经肽Y的促食欲作用也不因DFEN预处理而改变。对测试剂量DFEN的耐受程度和持续时间似乎部分取决于偶然（情境）因素，且与DFEN预处理（分别为低剂量和高剂量）对脑血清素（5-HT）测量值无影响或降低无关。
